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Insulin Expiration Chart (After Opening)

In-use insulin expiration is the number of days an insulin product remains usable after opening or first use. Many common insulin products expire after 28 days, while some such as Tresiba and Toujeo remain usable for 56 days. Always verify product-specific in-use stability before dispensing or calculating days supply.

This reference chart shows in-use expiration after opening for common insulin pens and vials. It is designed to help pharmacists and pharmacy technicians quickly review product stability that may affect patient counseling, refill timing, and days supply calculations.

Need to calculate insulin days supply? Use the insulin days supply calculator.

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Insulin expiration reference table

Insulin / Product	In-Use Expiration (Days)	Details	Calculate Days Supply
Admelog SoloStar Pen U-100	28 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Admelog U-100 3ml Vial	28 days	3ml per Vial • 300 units/container	Open Calculator
Admelog U-100 Vial 10ml	28 days	10ml per Vial • 1000 units/container	Open Calculator
Apidra 100 U/mL Vial	28 days	10ml per Vial • 1000 units/container	Open Calculator
Apidra Cartridge U-100 5 Cartridges	28 days	3ml per Cartridge, 15ml per Box • 300 units/container • 5 pens/cartridges per box	Open Calculator
Apidra SoloStar Pen U-100 5 Pens	28 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Basaglar KwikPen U-100 5 Pens	28 days	3ml per Cartridge, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Basaglar Tempo Pen U-100 5 Pens	28 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Fiasp FlexTouch Pen U-100 5 Pens	28 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Fiasp PenFill 5 Cartridges U-100	28 days	3ml per Cartridge, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Fiasp PumpCart 5 Cartridges U-100	4 days	1.6ml per Cartridge • 160 units/container • 5 pens/cartridges per box	Open Calculator
Fiasp U-100 Multi-dose Vial	28 days	10ml per Vial • 1000 units/container	Open Calculator
Humalog Cartridge U-100 5 Cartridges	28 days	3ml per Cartridge, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Humalog Junior KwikPen 5 Pens U-100	28 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Humalog KwikPen U-100 5 Pens	28 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Humalog KwikPen U-200 2 Pens	28 days	3ml per Pen, 10ml per Box • 2 unit priming dose • 600 units/container • 2 pens/cartridges per box	Open Calculator
Humalog Mix 50/50 KwikPen 5 Pens U-100	10 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Humalog Mix 50/50 U-100 Vial	28 days	10ml per Vial • 1000 units/container	Open Calculator
Humalog Mix 75/25 10ml Vial U-100	28 days	10ml per Vial • 1000 units/container	Open Calculator
Humalog Mix 75/25 KwikPen 5 Pens U-100	10 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Humalog Tempo Pen U-100 5 Pens	28 days	3ml per Cartridge, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Humalog U-100 Vial 10ml	28 days	10ml per Vial • 0 unit priming dose • 1000 units/container	Open Calculator
Humulin 70/30 KwikPen 5 Pens U-100	10 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Humulin 70/30 Vial U-100 10ml	31 days	10ml per Vial • 1000 units/container	Open Calculator
Humulin N KwikPen U-100 5 Pens	14 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Humulin N Vial U-100	31 days	10ml per Vial • 0 unit priming dose • 1000 units/container	Open Calculator
Humulin N Vial U-100 3ml	31 days	3ml per Vial • 300 units/container	Open Calculator
Humulin R U-100 10ml Vial	31 days	10ml per Vial • 1000 units/container	Open Calculator
Humulin R U-100 3ml Vial	31 days	3ml per Vial • 300 units/container	Open Calculator
Humulin R U-500 KwikPen 2 Pens	28 days	3ml per Pen, 6ml per Box • 5 unit priming dose • 1500 units/container • 2 pens/cartridges per box	Open Calculator
Humulin R U-500 Vial 20ml	40 days	20ml per Vial • 10000 units/container	Open Calculator
Insulin Aspart (U-100) Vial 10 mL	28 days	10 mL per Vial • 1000 units/container	Open Calculator
Insulin Aspart FlexPen 5 Pens U-100	28 days	3mL per Pen, 5 Pens per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Insulin Aspart Protamine-Insulin Aspart Mix 70/30 U-100 Vial10 mL	28 days	10 mL per Vial • 1000 units/container	Open Calculator
Insulin Aspart Protamine–Aspart Mix 70/30 FlexPen (5 Pens)	14 days	3 mL per Pen, 15 mL per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Insulin Aspart U-100 Cartridge 3mL (5-Pack)	28 days	5 × 3 mL Cartridges per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Insulin Glargine SoloStar U-300 3 Pens	56 days	1.5ml per Pen, 4.5ml per Box • 3 unit priming dose • 450 units/container • 3 pens/cartridges per box	Open Calculator
Insulin Glargine-YFGN U-100 5 Pens 10mL	28 days	3 mL per Pen, 5 Pens per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Insulin Glargine-YFGN U-100 Vial 10 mL	28 days	10 mL per Vial • 1000 units/container	Open Calculator
Lantus 10ml Vial U-100	28 days	10ml per Vial • 1000 units/container	Open Calculator
Lantus SoloStar 5 Pens U-100	28 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Levemir FlexTouch 5 Pens U-100	42 days	3ml per Pen, 15 ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Lispro JR U-100 3 ml KwikPen 5 Pens	28 days	3ml per Pen, 15 ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Lispro Mix 75/25 KwikPen 5 Pens U-100	10 days	3ml per Pen, 15 ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Lispro U-100 100/ml 10ml Vial	42 days	10ml per Vial • 1000 units/container	Open Calculator
Lispro U-100 Kwikpen 3ml 5 Pens	28 days	3ml per pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Lispro Vial U-100 10ml	28 days	10ml per Vial • 1000 units/container	Open Calculator
Novolin 70/30 FlexPen 5 Pens U-100	28 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Novolin 70/30 Vial U-100 10ml	42 days	10ml per Vial • 1000 units/container	Open Calculator
Novolin N FlexPen 5 Pens U-100	28 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Novolin N Vial U-100 10ml	42 days	10ml per Vial • 1000 units/container	Open Calculator
Novolin R FlexPen 5 Pens 100U	28 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Novolin R FlexPen 5 Pens U-100	28 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container	Open Calculator
Novolin R Vial U-100 10ml	42 days	10ml per Vial • 1000 units/container	Open Calculator
NovoLog FlexPen 5 Pens U-100	28 days	3ml per pen, 15ml per box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
NovoLog Mix 70/30 10ml Vial U-100	28 days	10ml per Vial • 1000 units/container	Open Calculator
NovoLog Mix 70/30 FlexPen 5 Pens U-100	14 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
NovoLog PenFill 5 Cartridges U-100	28 days	3ml per cartridge, 15ml per box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
NovoLog Vial U-100 10ml	28 days	10ml per Vial • 1000 units/container	Open Calculator
Semglee U-100 Pen 3mL 5 Pens	28 days	3 mL per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator
Semglee U-100 Vial 10 mL	28 days	10 mL per Vial • 1000 units/container	Open Calculator
Toujeo Max SoloStar 2 Pens U-300	56 days	3ml per Pen, 6ml per Box • 4 unit priming dose • 900 units/container • 2 pens/cartridges per box	Open Calculator
Toujeo SoloStar 3 Pens U-300	56 days	1.5ml per Pen, 4.5ml per Box • 3 unit priming dose • 450 units/container • 3 pens/cartridges per box	Open Calculator
Tresiba FlexTouch 3 Pens U-200	56 days	3ml per Pen, 9ml per Box • 2 unit priming dose • 600 units/container • 3 pens/cartridges per box	Open Calculator
Tresiba FlexTouch 5 Pens U-100	56 days	3ml per Pen, 15ml per Box • 2 unit priming dose • 300 units/container • 5 pens/cartridges per box	Open Calculator

Why expiration matters

Once opened or put into use, insulin products have specific stability limits. Using the correct in-use expiration helps support safe patient counseling and accurate dispensing decisions.

For pharmacists, in-use expiration can affect refill timing, product waste, and practical days supply calculations, especially when pen products are opened but not fully used.

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Frequently Asked Questions

What is in-use insulin expiration?

In-use insulin expiration is the number of days an insulin product remains usable after opening or first use.

Do all insulin pens expire after 28 days?

No. Many do, but some products have different in-use expiration periods, such as 10, 14, 31, 42, or 56 days depending on the product.

Does insulin expiration affect days supply?

Yes. Even if insulin remains in the pen or vial, the product may no longer be considered usable after its in-use expiration period.

Important note

Always use professional judgment and follow product labeling, payer requirements, and store workflow requirements when determining billed days supply or counseling on insulin stability.