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Insulin Priming Doses Chart

Insulin pen priming doses are the number of units injected before each dose to remove air and ensure accurate delivery. Most insulin pens use a 2-unit priming dose, although some products such as Toujeo SoloStar require 3 units and Humulin R U-500 KwikPen requires 5 units.

This reference chart shows priming doses for common insulin pens and related products. It is designed to help pharmacists and pharmacy technicians quickly review priming amounts that may affect effective insulin available for dosing and days supply calculations.

Need to calculate insulin days supply? Use the insulin days supply calculator.

Quick answer

Most common insulin pen priming doses are 2 units, while some products such as Toujeo SoloStar use 3 units and Humulin R U-500 KwikPen uses 5 units. Always verify product-specific priming before calculating billed days supply.

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Insulin Priming Doses Reference Table
Insulin / Product	Priming Dose	Details	Calculate Days Supply
Admelog SoloStar Pen U-100	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Apidra SoloStar Pen U-100 5 Pens	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Basaglar KwikPen U-100 5 Pens	2 units	3ml per Cartridge, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Basaglar Tempo Pen U-100 5 Pens	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Fiasp FlexTouch Pen U-100 5 Pens	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Fiasp PenFill 5 Cartridges U-100	2 units	3ml per Cartridge, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Humalog Cartridge U-100 5 Cartridges	2 units	3ml per Cartridge, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Humalog Junior KwikPen 5 Pens U-100	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Humalog KwikPen U-100 5 Pens	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Humalog KwikPen U-200 2 Pens	2 units	3ml per Pen, 10ml per Box • 600 units/container • 2 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Humalog Mix 50/50 KwikPen 5 Pens U-100	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 10 day in-use expiration	Open Calculator
Humalog Mix 75/25 KwikPen 5 Pens U-100	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 10 day in-use expiration	Open Calculator
Humalog Tempo Pen U-100 5 Pens	2 units	3ml per Cartridge, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Humulin 70/30 KwikPen 5 Pens U-100	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 10 day in-use expiration	Open Calculator
Humulin N KwikPen U-100 5 Pens	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 14 day in-use expiration	Open Calculator
Humulin R U-500 KwikPen 2 Pens	5 units	3ml per Pen, 6ml per Box • 1500 units/container • 2 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Insulin Aspart FlexPen 5 Pens U-100	2 units	3mL per Pen, 5 Pens per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Insulin Aspart Protamine–Aspart Mix 70/30 FlexPen (5 Pens)	2 units	3 mL per Pen, 15 mL per Box • 300 units/container • 5 pens/cartridges per box • 14 day in-use expiration	Open Calculator
Insulin Aspart U-100 Cartridge 3mL (5-Pack)	2 units	5 × 3 mL Cartridges per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Insulin Glargine SoloStar U-300 3 Pens	3 units	1.5ml per Pen, 4.5ml per Box • 450 units/container • 3 pens/cartridges per box • 56 day in-use expiration	Open Calculator
Insulin Glargine-YFGN U-100 5 Pens 10mL	2 units	3 mL per Pen, 5 Pens per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Lantus SoloStar 5 Pens U-100	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Levemir FlexTouch 5 Pens U-100	2 units	3ml per Pen, 15 ml per Box • 300 units/container • 5 pens/cartridges per box • 42 day in-use expiration	Open Calculator
Lispro JR U-100 3 ml KwikPen 5 Pens	2 units	3ml per Pen, 15 ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Lispro Mix 75/25 KwikPen 5 Pens U-100	2 units	3ml per Pen, 15 ml per Box • 300 units/container • 5 pens/cartridges per box • 10 day in-use expiration	Open Calculator
Lispro U-100 Kwikpen 3ml 5 Pens	2 units	3ml per pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Novolin 70/30 FlexPen 5 Pens U-100	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Novolin N FlexPen 5 Pens U-100	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Novolin R FlexPen 5 Pens 100U	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Novolin R FlexPen 5 Pens U-100	2 units	3ml per Pen, 15ml per Box • 300 units/container • 28 day in-use expiration	Open Calculator
NovoLog FlexPen 5 Pens U-100	2 units	3ml per pen, 15ml per box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
NovoLog Mix 70/30 FlexPen 5 Pens U-100	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 14 day in-use expiration	Open Calculator
NovoLog PenFill 5 Cartridges U-100	2 units	3ml per cartridge, 15ml per box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Semglee U-100 Pen 3mL 5 Pens	2 units	3 mL per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 28 day in-use expiration	Open Calculator
Toujeo Max SoloStar 2 Pens U-300	4 units	3ml per Pen, 6ml per Box • 900 units/container • 2 pens/cartridges per box • 56 day in-use expiration	Open Calculator
Toujeo SoloStar 3 Pens U-300	3 units	1.5ml per Pen, 4.5ml per Box • 450 units/container • 3 pens/cartridges per box • 56 day in-use expiration	Open Calculator
Tresiba FlexTouch 3 Pens U-200	2 units	3ml per Pen, 9ml per Box • 600 units/container • 3 pens/cartridges per box • 56 day in-use expiration	Open Calculator
Tresiba FlexTouch 5 Pens U-100	2 units	3ml per Pen, 15ml per Box • 300 units/container • 5 pens/cartridges per box • 56 day in-use expiration	Open Calculator

Why priming matters

Priming removes air from insulin pens before injection and helps ensure accurate dose delivery. However, those priming units are not part of the therapeutic dose. Repeated priming can reduce the effective insulin available for patient use.

For pharmacists, this can affect insulin days supply calculations, refill timing, and documentation during billing or audit review.

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Frequently Asked Questions

What is the usual insulin pen priming dose?

Many insulin pens use a 2-unit priming dose, but some products use a different amount.

Does priming affect days supply?

Yes. Priming uses insulin that is not part of the therapeutic dose, so it can reduce the effective insulin available for patient use.

Important note

Always use professional judgment and follow product labeling, payer requirements, and store workflow requirements when determining billed days supply.